Subscribe
Logo smallSearch

What is glycation and why not only diabetics should know about it

MedExpress Team

Dr n. med. Marek Derkacz

Published July 11, 2023 09:11

What is glycation and why not only diabetics should know about it - Header image
Fot. arch. red.
The phenomenon of protein glycation has been known to us for more than 110 years. Already at the beginning of the 20th century, as in 1912, Louis Camille Maillard was the first researcher to describe the reaction of spontaneous bonding between amino acids and simple sugars and referred to it as the "browning reaction." Initially, this process was associated only with nutrition. However, in the 1980s, Cerami et al. pointed out that the phenomenon of increased glycation is inextricably linked to the aging process of cells and tissues.

Since the impact of a disease like diabetes on the state of the body was already referred to as "accelerated aging," many of the studies focusing attention on glycation processes involved people with diabetes. We now know that the AGEs that are formed cause both direct and indirect damage to many cellular structures - by inducing oxidative stress and the phenomena of glycation and lipoxidation.

Glycation is a process that is closely associated with chronic hyperglycemia taking place primarily in diabetes, but also in the pre-diabetic state of abnormal fasting glucose and abnormal glucose tolerance. Elevated blood glucose levels lead to glycation, a process in which a glucose molecule attaches to a protein without enzymes. Glycation is a reaction between sugars and proteins that leads to the formation of so-called advanced glycation end products (AGEs). AGEs are harmful to our bodies because they can affect the structure and function of proteins.

It is AGEs that may be responsible for the development of diabetes complications, such as angiopathy (vascular damage : microangiopathy and macroangiopathy; neuropathy (nerve damage), and nephropathy (kidney damage), among others.

The process of glycation, occurs in both type 1 diabetes and type 2 diabetes. However, the mechanisms and factors leading to it may vary depending on the type of diabetes and, in addition, the presence of insulin resistance and hyperinsulinemia.

...

Content locked

To gain access to the complete English section of the Medexpress.pl, kindly reach out to us at [email protected].

If you already have an account, please log in

Szukaj nowych pracowników

Dodaj ogłoszenie już za 4 zł dziennie*.

* 4 zł netto dziennie. Minimalny okres ekspozycji ogłoszenia to 30 dni.

Najciekawsze oferty pracy (przewiń)

Read also

K-Bukiel-2015---Kopia-mala2
Krzysztof Bukiel

To myself or from myself. Current comment

Feb. 11, 2022
Leszek Borkowski
Leszek Borkowski

Pharmaceutical Verification Exam

May 12, 2022
Leszek Borkowski
Dr n. farm. Leszek Borkowski

Slimming with pharmacology

July 6, 2022
27.11.2012 WARSZAWA , PROFESOR WIESLAW JEDRZEJCZAK W NOWYM ODDZIALE TRANSPLANTACJI SZPIKU W SZPITALU PRZY BANACHA .FOT. ADAM STEPIEN / AGENCJA GAZETA
Aug. 18, 2022
Walenty-Zajdel_zdjecie
Aug. 19, 2022
27.11.2012 WARSZAWA , PROFESOR WIESLAW JEDRZEJCZAK W NOWYM ODDZIALE TRANSPLANTACJI SZPIKU W SZPITALU PRZY BANACHA .FOT. ADAM STEPIEN / AGENCJA GAZETA
Prof. Wiesław W. Jędrzejczak

Experiment

Jan. 15, 2023
Msolecka
FeatureMałgorzata Solecka

Two words are enough for a wise head

Feb. 19, 2024