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Groundbreaking clinical trial on novel treatment for Ewing's sarcoma at Mother and Child Institute

MedExpress Team

medexpress.pl

Published Nov. 8, 2023 08:29

Groundbreaking clinical trial on novel treatment for Ewing's sarcoma at Mother and Child Institute - Header image
IMiD's Department of Oncology has launched Project BUTTERFLY, a non-commercial clinical trial evaluating the efficacy of naxitamab. It is a novel treatment for Ewing's sarcoma. The aim of the study is to improve the diagnosis and treatment of children with refractory and recurrent forms of this cancer. Eligible for the program are patients between the ages of 2 and 21 for whom previous medical management has failed. The first patient - 12-year-old Jacob - received immunotherapy on October 25.

Ewing's sarcoma is a malignant tumor, the second most common bone tumor in children and young adults. It mostly develops in bones, such as the femur, pelvis or ribs, but can also appear in soft tissues - such as muscle tissue. The peak incidence is between the ages of 15 and 19, although younger children are often affected. Unfortunately, more than half of patients also have metastatic lesions at the time of diagnosis. Therefore, it is important to diagnose quickly and implement appropriate treatment. However, about 20-30% of patients face treatment failure - in order to minimize this percentage, the Mother and Child Institute has launched Project BUTTERFLY, a study of a novel treatment method for Ewing's sarcoma patients.

Groundbreaking study

Project BUTTERFLY is one of the first immunotherapies in bone tumors and the first naxitamab therapy in Ewing's sarcoma worldwide. The trial aims to improve the diagnosis and treatment of patients with refractory and relapsed disease, as well as standardize and unify diagnostic and therapeutic approaches. It will also enable the creation of a biobank to store patients' biological samples. This, in turn, will help further the dev...

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